Targeting Subsets of Mammalian Neurons

Targeting of human antigen-presenting cell subsets.

Antigen-presenting cells are a heterogeneous group of cells that are characterized by their functional specialization. Consequently, targeting specific antigen-presenting cell subsets offers opportunities to induce distinct T cell responses. Here we report on the generation and use of nanobodies (Nbs) to target lentivectors specifically to human lymph node-resident myeloid dendritic cells, demo...

Targeting of mammalian glucose transporters.

Localization and targeting of voltage-dependent ion channels in mammalian central neurons.

The intrinsic electrical properties and the synaptic input-output relationships of neurons are governed by the action of voltage-dependent ion channels. The localization of specific populations of ion channels with distinct functional properties at discrete sites in neurons dramatically impacts excitability and synaptic transmission. Molecular cloning studies have revealed a large family of gen...

TWH Regulates the Development of Subsets of Spinal Cord Neurons

Thymocyte winged helix (TWH) is a putative transcription factor expressed in the developing neural tube. At midgestation, TWH expression identifies subsets of spinal cord motor neurons and interneurons. TWH-expressing motor neurons were restricted to specific spinal cord levels, distinguishing motor neurons at lumbar from those at cervical levels. To understand the developmental role of TWH, we...

Uptake of Protein by Mammalian Neurons

Although the uptake of macromolecules by neurons often figures in theories of function in the nervous system (see reference 18), such uptake has actually been demonstrated only in a few instances, usually under special circumstances. In general, exogenous tracer proteins have been shown either to be stopped by "barriers" between the circulation and the nervous system (see references 3, 29) or t...